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Updated: Jun 12, 2026
06:47
Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
Published on: January 28, 2021
Hypolipidemic effect of arborium plus in experimentally induced hypercholestermic rabbits
Devarakonda Murty1, Enjamoori Rajesh, Doonaboina Raghava
1Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, India. devarakonda6@gmail.com
Summary
This study shows Arborium Plus, an Ayurvedic herbal remedy, effectively lowers cholesterol and triglycerides in rabbits with high cholesterol. It offers a potential natural approach to managing hypercholesterolemia and reducing heart disease risk.
Area of Science:
- Cardiovascular Pharmacology
- Phytomedicine
- Lipid Metabolism
Background:
- Hypercholesterolemia is a significant risk factor for coronary artery disease.
- Current treatments may have limitations, driving interest in natural alternatives.
- Ayurvedic medicine offers traditional formulations for health management.
Purpose of the Study:
- To evaluate the hypolipidemic efficacy of Arborium Plus in experimentally induced hypercholesterolemia.
- To assess the impact of Arborium Plus on key lipid parameters and inflammatory markers.
- To compare the effects of Arborium Plus with a standard statin treatment.
Main Methods:
- Hypercholesterolemia was induced in rabbits using a 1% cholesterol diet for 8 weeks.
- Treatment groups included control, cholesterol-only, Arborium Plus with cholesterol, and atorvastatin with cholesterol.
- Lipid profiles (TG, TC, LDL, HDL) and high-sensitivity C-reactive protein (hs-CRP) were measured.
Main Results:
- Hypercholesterolemic rabbits showed significant increases in triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), atherogenic index (AI), and hs-CRP.
- Arborium Plus treatment significantly reduced these elevated lipid parameters and hs-CRP levels.
- The effects of Arborium Plus were comparable to atorvastatin in reducing hyperlipidemia.
Conclusions:
- Arborium Plus demonstrates significant hypolipidemic and anti-inflammatory effects in a rabbit model of hypercholesterolemia.
- The formulation, containing Hippophae rhamnoides and Rhododendron arboreum, shows potential as a natural therapeutic agent.
- Further research is warranted to explore its clinical application in managing cardiovascular risk factors.
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