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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Inflammation01:38

Inflammation

Overview
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...

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Related Experiment Video

Updated: Jun 12, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Role for basophils in systemic anaphylaxis.

Hajime Karasuyama, Yusuke Tsujimura, Kazushige Obata

    Chemical Immunology and Allergy
    |June 4, 2010
    PubMed
    Summary

    Basophils, rare immune cells, are key players in IgG-mediated anaphylaxis, not IgE-mediated reactions. Depleting basophils protects against anaphylactic shock, revealing distinct allergic pathways.

    Area of Science:

    • Immunology
    • Allergy Research
    • Leukocyte Biology

    Background:

    • Basophils, rare leukocytes, have historically enigmatic functions compared to mast cells.
    • Limited research tools and rarity hampered basophil studies.
    • Recent findings highlight basophils' crucial roles in allergic responses and immune regulation.

    Purpose of the Study:

    • To elucidate the distinct roles of basophils and mast cells in systemic anaphylaxis.
    • To investigate the involvement of basophils in different immunoglobulin-mediated anaphylactic pathways.

    Main Methods:

    • Utilized mouse models to study systemic anaphylaxis.
    • Compared IgE-mediated and IgG-mediated anaphylaxis pathways.
    • Performed in vivo basophil depletion experiments.

    More Related Videos

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
    10:22

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

    Published on: September 16, 2011

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Related Experiment Videos

    Last Updated: Jun 12, 2026

    Basophil Activation Test for Allergy Diagnosis
    07:22

    Basophil Activation Test for Allergy Diagnosis

    Published on: May 31, 2021

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
    10:22

    Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

    Published on: September 16, 2011

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Main Results:

    • Basophils are dispensable for IgE-mediated anaphylaxis, unlike mast cells.
    • Basophils play a major role in IgG-mediated systemic anaphylaxis.
    • In vivo basophil depletion prevented anaphylactic death in mice.

    Conclusions:

    • Identified two distinct pathways for allergen-induced systemic anaphylaxis: one involving basophils, IgG, and platelet-activating factor, and the classical pathway involving mast cells, IgE, and histamine.
    • Basophils are critical mediators of IgG-driven anaphylaxis.
    • Basophils are key players in the immune system, particularly in specific allergic reactions.