Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Allergic Reactions02:06

Allergic Reactions

Overview
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anaphylaxis in children and adolescents: The European Anaphylaxis Registry.

The Journal of allergy and clinical immunology·2016
Same author

[Allergy risk of transgenic foods, methods for prevention].

Presse medicale (Paris, France : 1983)·2003
Same journal

Educational programmes in food allergy.

Chemical immunology and allergy·2015
Same journal

Prevention of food allergy.

Chemical immunology and allergy·2015
Same journal

The effects of food allergy on quality of life.

Chemical immunology and allergy·2015
Same journal

Worldwide food allergy labeling and detection of allergens in processed foods.

Chemical immunology and allergy·2015
Same journal

Food allergy: psychosocial impact and public policy implications.

Chemical immunology and allergy·2015
Same journal

Nutritional aspects and diets in food allergy.

Chemical immunology and allergy·2015
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Anaphylaxis to general anesthetics.

Anne Moneret-Vautrin, P Michel Mertes

    Chemical Immunology and Allergy
    |June 4, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Hypersensitivity reactions to anesthesia, often caused by neuromuscular blocking agents, occur in 1 in 3,180 anesthetics. Prompt investigation is crucial for identifying culprits and preventing future allergic events.

    More Related Videos

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
    08:16

    Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

    Published on: July 23, 2020

    Related Experiment Videos

    Last Updated: Jun 12, 2026

    Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
    08:49

    Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

    Published on: October 16, 2013

    Measuring Local Anaphylaxis in Mice
    07:49

    Measuring Local Anaphylaxis in Mice

    Published on: October 14, 2014

    Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
    08:16

    Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

    Published on: July 23, 2020

    Area of Science:

    • Anesthesiology
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Hypersensitivity reactions to anesthetics are a significant concern, with an incidence ranging from 1 in 13,000 to 1 in 3,180 anesthetics.
    • Mortality rates for these reactions are between 3% and 9%, with 90% occurring during anesthesia induction.
    • IgE-dependent reactions, characterized by cardiovascular collapse and bronchospasm, are predominant.

    Purpose of the Study:

    • To investigate the incidence and causes of hypersensitivity reactions during anesthesia.
    • To identify the primary agents responsible for these reactions.
    • To emphasize the importance of thorough investigation and diagnosis of suspected anesthetic allergies.

    Main Methods:

    • Review of anesthetic hypersensitivity reaction data.
    • Identification of common causative agents, including neuromuscular blocking agents, latex, antibiotics, and vital dyes.
    • Discussion of diagnostic approaches including tryptase assay, skin tests, and IgE quantification.

    Main Results:

    • Neuromuscular blocking agents are the leading cause (50-70%), often due to IgE-mediated responses and potential cross-reactivity.
    • Latex allergy is the second most common cause, followed by antibiotics and beta-lactams.
    • Increasing incidence of anaphylaxis to vital dyes and chlorhexidine noted.

    Conclusions:

    • Comprehensive investigation is essential for suspected anesthetic hypersensitivity reactions to confirm diagnosis and identify causative agents.
    • Understanding cross-reactivity, particularly with neuromuscular blocking agents, is critical for patient safety.
    • Recommendations for future anesthetic procedures should be based on confirmed drug allergies and sensitization profiles.