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Rasagiline improves learning and memory in young healthy rats
Fong-Kuan Wong1, Sherry Hung-Wah Lee, Zeenat Atcha
1GSK R&D China, Singapore Research Centre, Biopolis at One-North, 11 Biopolis Way, Singapore 138667, Singapore.
Behavioural Pharmacology
|June 4, 2010
Summary
Rasagiline, a monoamine oxidase-B inhibitor, improved learning and memory in rats. This study suggests rasagiline
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Cognitive impairment is a hallmark of neurodegenerative disorders.
- Rasagiline is a selective monoamine oxidase-B inhibitor.
Purpose of the Study:
- To investigate the procognitive effects of rasagiline in healthy young rats.
- To evaluate rasagiline's impact on novel object recognition and spatial learning.
Main Methods:
- Lister-Hooded rats were administered rasagiline (0.3 and 1 mg/kg) or saline.
- Cognitive function was assessed using a novel object recognition test and a modified water maze task.
Main Results:
- Rasagiline significantly enhanced object recognition memory, with a dose-dependent effect.
- A small positive effect of rasagiline (1 mg/kg) on spatial learning was detected in the water maze task.
- These procognitive effects were observed in young healthy rats.
Conclusions:
- Rasagiline demonstrates procognitive effects in healthy rats.
- Monoamine oxidase-B inhibitors may offer a potential symptomatic treatment for cognitive deficits in neurodegenerative diseases.
