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Updated: Jun 12, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
Published on: August 11, 2023
Dose selection of corifollitropin alfa by modeling and simulation in controlled ovarian stimulation
R de Greef1, A S Zandvliet, A F J de Haan
1Global Drug Metabolism & Pharmacokinetics, Merck Research Labs, Merck Sharp & Dohme, Oss, The Netherlands.
Abstract:
In controlled ovarian stimulation (COS), a single subcutaneous dose of corifollitropin alfa is used to initiate and sustain multifollicular growth for 7 days. The objective of this study was to determine the optimal dose of corifollitropin alfa. A pharmacokinetic model was developed to describe the time profile of corifollitropin alfa concentrations. Multiple parameters reflecting ovarian response were included in a pharmacokinetic-pharmacodynamic (PK-PD) model framework. An early decline in serum inhibin B was shown to be a sensitive marker for COS failure. Simulations were performed to select the lowest corifollitropin alfa dose that would result in a minimal cancellation rate: 100 microg for a group of women weighing
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