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Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug is...
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Energy Budgets and Reproductive Strategies

Organisms must balance energy intake with the energy required for growth, maintenance, and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species reproduce only once in their lifetime, often investing most available resources into that single reproductive event. Iteroparous species, by contrast, reproduce multiple times over their lifetimes, typically allocating fewer resources to any single...
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Establishing an Octopus Ecosystem for Biomedical and Bioengineering Research
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Institutional open access funds: now is the time.

Charles D Eckman1, Beth T Weil

  • 1Library, University of California Berkeley, Berkeley, California, United States of America.

Plos Biology
|June 4, 2010
PubMed
Summary

The Berkeley OA fund supports immediate open access (OA) publishing, costing less than 1% of traditional subscriptions. Institutions should adopt OA funds for universal research access, especially during economic challenges.

Area of Science:

  • Scholarly Communication
  • Library Science
  • Open Access Publishing

Background:

  • The current subscription model for digital journals incurs significant overhead costs beyond the subscription price.
  • These costs include staff-intensive license negotiations, system architecture maintenance for access control, and managing legal obligations.
  • The economic crisis heightens the need to explore alternative funding models due to the challenges of justifying subscription investments.

Purpose of the Study:

  • To evaluate the effectiveness and financial viability of an institutional open access (OA) fund.
  • To advocate for the adoption of OA funds as a sustainable model for scholarly communication.
  • To compare the costs of OA publishing with traditional subscription models.

Main Methods:

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  • Tracking the number of articles made immediately open access through the OA fund.
  • Analyzing the financial investment in the OA fund versus library investments in closed-access subscriptions.
  • Monitoring the evolving OA landscape, including publisher options and licensing negotiations.
  • Main Results:

    • The Berkeley OA fund has supported 43 immediate OA publications, with 44 more in progress.
    • The projected annual cost to maintain the fund is US$45,000, representing less than 1% of the library's US$6.2 million investment in closed-access subscriptions.
    • OA publishing, even considering the full scope, is significantly more cost-effective than the subscription model when overheads are included.

    Conclusions:

    • Institutional OA funds are a cost-effective alternative to traditional subscription models.
    • Adopting OA funds promotes universal access to research output and aligns with institutional values.
    • The current economic climate necessitates a shift towards exploring and implementing alternative funding models like OA funds for scholarly communication.