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Related Experiment Video

Updated: Jun 12, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Skin barrier in atopic dermatitis.

Flavia Alvim Sant'Anna Addor¹, Valeria Aoki

¹Universidade de São Paulo, Department of Dermatology, Brazil. flavia@medcinonline.com.br <flavia@medcinonline.com.br>

Anais Brasileiros De Dermatologia

|June 4, 2010

Summary

This study highlights the skin barrier's active role in inflammation and adaptive functions. Biophysical parameters like stratum corneum hydration and water loss aid in monitoring skin conditions such as atopic dermatitis.

Area of Science:

Dermatology
Skin Biology
Epidermal Physiology

Background:

Research on the skin barrier has evolved significantly since the 1960s, revealing its resistance and permeability characteristics.
The "brick and mortar" model, with corneocytes as bricks and intercellular lipids as mortar, is widely accepted for stratum corneum stability.
Odland bodies are crucial for understanding stratum corneum stability.

Purpose of the Study:

To explore the dynamic and adaptive functions of the stratum corneum.
To understand the skin barrier's role in inflammatory responses.
To highlight the clinical relevance of biophysical parameters in monitoring skin barrier abnormalities.

Main Methods:

Review of existing research on skin barrier structure and function.

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Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin

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Analysis of the role of stratum corneum in metabolic and inflammatory processes.

Examination of biophysical parameters for assessing skin barrier integrity.

Main Results:

The stratum corneum is an active metabolic structure with adaptive functions, interacting dynamically with epidermal layers.
The skin barrier participates in inflammatory responses, including melanocyte activation, angiogenesis, and fibroplasia.
Stratum corneum hydration and transepidermal water loss are key biophysical parameters linked to barrier damage.

Conclusions:

Skin barrier abnormalities, like those in atopic dermatitis, manifest as dry skin and can be monitored using biophysical parameters.
Stratum corneum hydration and transepidermal water loss offer sensitive, less invasive methods for patient monitoring.
Understanding the skin barrier's active role is crucial for managing inflammatory skin conditions.