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[Infection by hepatitis C virus in patients on hemodialysis: prevalence and risk factors]

José Rafael Leão1, Fabio Heleno de Lima Pace, Julio Maria Fonseca Chebli

  • 1Programa de Pós-Graduação em Ciências da Saúde, Núcleo de Pesquisa em Gastroenterologia, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG. jrleaodr@yahoo.com.br

Arquivos De Gastroenterologia
|June 4, 2010
PubMed

Insights

Hepatitis C virus (HCV) infection is highly prevalent in hemodialysis patients. Prolonged dialysis treatment and a history of sexually transmitted diseases are significant risk factors for HCV infection.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Nephrology

Context:

  • Patients with chronic kidney disease undergoing hemodialysis face a heightened risk of hepatitis C virus (HCV) infection.
  • High HCV prevalence rates are documented globally in dialysis units.
  • HCV infection is linked to reduced life expectancy in hemodialysis and transplant patients.

Purpose:

  • To determine the prevalence of HCV infection among hemodialysis patients.
  • To identify significant risk factors associated with HCV acquisition in this population.

Summary:

  • A cross-sectional study in 2007 tested 236 hemodialysis patients for anti-HCV antibodies and HCV-RNA.
  • Chronic HCV infection was confirmed in 10.6% of patients.
  • Multivariate analysis identified longer duration on hemodialysis (over 10 years) and a history of sexually transmitted diseases as key risk factors.
  • HCV-infected patients exhibited significantly higher mean serum ALT levels.

Impact:

  • Highlights the substantial burden of HCV in hemodialysis settings.
  • Identifies critical risk factors, enabling targeted prevention strategies.
  • Underscores the need for vigilant screening and management of HCV in renal disease patients.
Abstract

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