Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stagewise, adaptive dose allocation for quantal response dose-response studies.

P I Feder1, D W Hobson, C T Olson

  • 1Battelle, Columbus, OH 43201.

Neuroscience and Biobehavioral Reviews
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A microbial safari: finding evidence of <i>Mycobacterium bovis</i> DNA in soil from the Kruger National Park, South Africa.

Microbiology spectrum·2025
Same author

Determination of (238)U, (232)Th and (40)K activity concentrations in riverbank soil along the Chao Phraya river basin in Thailand.

Journal of environmental radioactivity·2014
Same author

Preliminary report on the use of tantalum oxide, Type 400.

Industrial medicine & surgery·2010
Same author

Comparing and evaluating alternative (in vitro) tests on their ability to predict the Draize maximum average score.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats.

Toxicological sciences : an official journal of the Society of Toxicology·2002
Same author

Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning.

Toxicological sciences : an official journal of the Society of Toxicology·2002
Same journal

Circuit transitions from fear and anxiety to suicidal brain states.

Neuroscience and biobehavioral reviews·2026
Same journal

Dissecting first-episode psychosis heterogeneity with clustering analyses: a systematic review.

Neuroscience and biobehavioral reviews·2026
Same journal

Irisin and anxiety-like behaviors: Mechanistic integration of peripheral-central crosstalk, neuroinflammation and neural plasticity.

Neuroscience and biobehavioral reviews·2026
Same journal

Efficacy of Non-Invasive Brain Stimulation in Alzheimer's Disease: An Umbrella Review of Meta-Analyses.

Neuroscience and biobehavioral reviews·2026
Same journal

Rhythms of interaction - the timescales of social coordination and why they matter.

Neuroscience and biobehavioral reviews·2026
Same journal

Neural Bases of Memory Development: Insights from Magnetic Resonance Imaging.

Neuroscience and biobehavioral reviews·2026
See all related articles

This study introduces a stagewise approach for dose-response studies to precisely estimate extreme percentiles, like the ED95 dose, efficiently. This method optimizes subject allocation in experiments, maximizing information gained at each stage.

Area of Science:

  • Biostatistics
  • Pharmacometrics
  • Experimental Design

Background:

  • Dose-response studies aim to precisely estimate key parameters, such as the ED95 dose.
  • Efficiently estimating these parameters requires minimizing the number of experimental subjects.
  • Current methods may not fully optimize information gain across sequential experimental stages.

Purpose of the Study:

  • To develop and illustrate stagewise methods for dose allocation in dose-response studies.
  • To enhance the precision of estimating extreme percentiles (e.g., ED95) with minimal subjects.
  • To compare the anticipated precision improvements of different dose allocation strategies.

Main Methods:

  • Utilizes a stagewise allocation strategy for assigning subjects to experimental dose levels.

Related Experiment Videos

  • Incorporates updated estimates of dose-response distribution parameters and their uncertainties at each stage.
  • Employs specialized methods and computer programs to evaluate experimental plan sensitivities for dichotomous responses.

    • Main Results:

    • Demonstrates a method to dynamically adjust subject allocation based on accumulating experimental data.
    • Compares competing dose allocation plans based on their expected impact on estimation precision.
    • Provides an illustrative example of the stagewise dose allocation strategy in practice.

    Conclusions:

    • Stagewise dose allocation strategies can significantly improve the precision of estimating extreme dose-response percentiles.
    • This adaptive approach maximizes information extraction from each experimental subject.
    • The described methods offer a framework for more efficient and precise dose-response study designs.