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Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients

Yusuf Tavil1, Nihat Sen, Hüseyin Yazici

  • 1Gazi University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey. yusuftavil@gmail.com

Platelets
|June 5, 2010
PubMed

Insights

Diabetic patients with coronary heart disease show significantly higher mean platelet volume (MPV) compared to controls. This finding highlights MPV as a potential indicator in diabetes and heart disease research.

Area of Science:

  • Cardiology
  • Endocrinology
  • Hematology

Background:

  • Mean platelet volume (MPV) reflects platelet activation, a key factor in coronary heart disease (CHD) pathophysiology.
  • Platelet activation is implicated in the progression of diabetes mellitus (DM).

Purpose of the Study:

  • To investigate if mean platelet volume (MPV) is elevated in type 2 diabetic patients.
  • To assess the relationship between diabetic complications and MPV levels.

Main Methods:

  • Compared MPV in 158 type 2 diabetic patients with coronary artery disease (CAD) against 100 controls without diabetes and normal coronary angiography.
  • Utilized the Gensini scoring system to quantify the extent of coronary heart disease (CHD).

Main Results:

  • MPV was significantly higher in diabetic patients with CHD (9.79 ± 1.5 fl) compared to controls (8.3 ± 0.9 fl) (P<0.001).
  • Coronary heart disease (CHD) presence was associated with increased MPV (Odds Ratio: 2.31, 95% CI: 1.55-4.42, p<0.001).

Conclusions:

  • Diabetic patients with coronary heart disease exhibit significantly elevated MPV values.
  • MPV may serve as a valuable biomarker in understanding the interplay between diabetes and cardiovascular disease.
Abstract

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