Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
The Bronchial Tree01:23

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Immune Cell Landscape Altered by Exposure to HIV, <i>Schistosoma</i> and Their Combination.

International journal of molecular sciences·2026
Same author

Personalized Combination of a Ketogenic Diet and Low-Dose Semaglutide for Cardiometabolic Health: A Retrospective Case Series.

Journal of personalized medicine·2026
Same author

A Chimeric Airway Model Enables Evaluation of Essential Genes In Vivo.

American journal of respiratory cell and molecular biology·2026
Same author

Semaglutide Induces Oxidative Stress and Differentially Modulates mTOR-Dependent Growth and Invasion in Human Trophoblast Cell Models: Implications for Placental Function.

Current issues in molecular biology·2026
Same author

Testosterone Replacement Therapy in Women Is Associated with Improved Symptom Burden and Favorable Biomarker Changes: A Retrospective Observational Study.

Journal of personalized medicine·2026
Same author

Assessment of ad hoc lung cancer screening at a safety net hospital.

Journal of thoracic disease·2026
Same journal

Lxrα Deficiency Primes Retinal Degeneration, but Aging Drives Disease Severity.

The American journal of pathology·2026
Same journal

MYC is functionally required in both normal and neoplastic Meibomian glands.

The American journal of pathology·2026
Same journal

Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis.

The American journal of pathology·2026
Same journal

Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

The American journal of pathology·2026
Same journal

APOE4 as a Modifier of Chemotherapy Response.

The American journal of pathology·2026
Same journal

Spatial Pathobiology in the Omics Era: Transforming Modern Pathology.

The American journal of pathology·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

Tracheal Basal cells: a facultative progenitor cell pool.

Brook B Cole1, Russell W Smith, Kimberly M Jenkins

  • 1Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, Colorado, USA.

The American Journal of Pathology
|June 5, 2010
PubMed
Summary
This summary is machine-generated.

Tracheal epithelium repair involves two basal cell types that regenerate damaged airway cells. These basal cells, both keratin 14-negative and -positive, coordinate to restore the airway lining after injury.

More Related Videos

Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells
10:46

Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells

Published on: June 14, 2022

Related Experiment Videos

Last Updated: Jun 12, 2026

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea
11:52

Isolation of Basal Cells and Submucosal Gland Duct Cells from Mouse Trachea

Published on: September 14, 2012

Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells
10:46

Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells

Published on: June 14, 2022

Area of Science:

  • Pulmonary Medicine
  • Stem Cell Biology
  • Epithelial Biology

Background:

  • The tracheal epithelium contains progenitor cells crucial for tissue repair after injury.
  • Previous models hypothesized multipotential keratin 14-expressing cells (K14ECs) as primary progenitors for Clara and ciliated cells.
  • The precise hierarchical organization of tracheal stem and progenitor cells remained incompletely understood.

Purpose of the Study:

  • To investigate the roles of different tracheal progenitor cell pools in epithelial homeostasis and repair.
  • To evaluate the contribution of basal cell subsets to tracheal regeneration following naphthalene injury.
  • To refine the model of tracheal stem cell hierarchy based on experimental findings.

Main Methods:

  • Gene expression analysis of steady-state and naphthalene-injured trachea.
  • Histomorphometric analysis to assess cell populations and tissue structure.
  • In vivo studies utilizing naphthalene to induce epithelial injury and observe regenerative processes.

Main Results:

  • The steady-state tracheal epithelium is maintained by secretory and basal progenitor cells.
  • Basal cells are further divided into keratin 14-negative and -positive subsets.
  • Following naphthalene injury, both basal cell types up-regulate keratin 14, proliferate, and generate differentiated Clara and ciliated cells, coordinating epithelial restoration.

Conclusions:

  • Tracheal epithelial repair is a coordinated effort involving distinct basal cell progenitor pools.
  • A facultative basal cell progenitor pool, encompassing both keratin 14-negative and -positive cells, plays a key role in tracheal regeneration.
  • The proposed model of tracheal stem cell hierarchy requires revision to incorporate the dynamic and coordinated function of basal progenitors.