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Related Experiment Video

Updated: Jun 12, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Case finding for chronic obstructive pulmonary disease: a model for optimising a targeted approach.

Rachel E Jordan¹, Kin-bong Hubert Lam, Kar Keung Cheng

¹Unit of Public Health, Epidemiology & Biostatistics, Public Health Building, University of Birmingham, Edgbaston, Birmingham, UK. r.e.jordan@bham.ac.uk

|June 5, 2010

Summary

A proactive strategy for identifying undiagnosed chronic obstructive pulmonary disease (COPD) could find 70% more cases than opportunistic methods alone. This approach may significantly reduce hospitalizations and deaths in England.

Related Experiment Videos

Last Updated: Jun 12, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Area of Science:

Pulmonary Medicine
Public Health
Epidemiology

Background:

Chronic obstructive pulmonary disease (COPD) is widely underdiagnosed globally.
Effective case-finding strategies are crucial for the upcoming English National Clinical Strategy for COPD.
Current methods for identifying undiagnosed COPD are not well-established.

Purpose of the Study:

To quantify the prevalence of undiagnosed clinically significant COPD in England.
To compare the effectiveness of active versus opportunistic case-finding approaches for COPD.

Main Methods:

Cross-sectional analysis of the Health Survey for England (1995-1996) data.
Model comparing active (questionnaires + opportunistic) and opportunistic-only case-finding.
Inclusion of 20,496 participants aged >=30 years with lung function measurements.

Main Results:

4.7% of participants had clinically significant COPD, with 86.5% undiagnosed.
Active case-finding identified 70% more new cases than opportunistic methods alone.
Potential to reduce annual hospitalizations by 3300 and deaths by 2885 over 3 years.

Conclusions:

Significant undiagnosed COPD exists in the population.
Systematic, active case-finding may be more effective than opportunistic methods.
Further prospective studies are needed to assess cost-effectiveness.