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A new diabetic mouse model derived from the ddY strain
Ichiro Noge1, Yoshiyuki Kagawa, Toshio Maeda
1Department of Clinical Pharmaceutics & Pharmacy Practice, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Biological & Pharmaceutical Bulletin
|June 5, 2010
Summary
Selective breeding created hyperglycemic (ddY-H) mice that spontaneously develop insulin resistance and diabetic symptoms. Normoglycemic (ddY-L) mice serve as controls, with traits inherited recessively.
Area of Science:
- * Metabolic research
- * Animal models of diabetes
Background:
- * Hyperglycemia and impaired glucose tolerance are key features of diabetes.
- * Developing reliable animal models is crucial for understanding diabetes pathogenesis and testing interventions.
Purpose of the Study:
- * To develop and characterize a novel mouse model for spontaneous diabetes.
- * To investigate the genetic basis of impaired glucose tolerance and insulin resistance.
Main Methods:
- * Selective breeding of ddY mice to establish hyperglycemic (ddY-H) and normoglycemic (ddY-L) lines.
- * Assessment of glucose tolerance, serum glucose and insulin levels, and urinary parameters.
- * Cross-mating experiments to evaluate the inheritance pattern of impaired glucose tolerance.
Main Results:
- * ddY-H mice exhibited elevated glucose levels after fasting and impaired glucose tolerance.
- * Spontaneous insulin resistance and diabetic symptoms, including increased body mass and urinary sugar excretion, were observed in ddY-H mice.
- * Impaired glucose tolerance was found to be recessively inherited.
Conclusions:
- * ddY-H mice represent a valuable model for studying spontaneous insulin resistance and diabetic symptoms.
- * ddY-L mice are suitable as control subjects in studies involving the ddY-H model.
- * The genetic basis for the observed diabetic phenotype is recessive.
