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Related Experiment Video

Updated: Jun 12, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Microcirculatory evaluation in sepsis: a difficult task.

Ivan H J Koh1, Jose L Menchaca-Diaz, Tarso H Koh

  • 1Department of Surgery, Federal University of São Paulo, São Paulo, Brazil. ivankoh@terra.com.br

Shock (Augusta, Ga.)
|June 5, 2010
PubMed
Summary
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This review connects experimental findings on abdominal organ microvascular changes to clinical observations in early severe sepsis. It aims to improve understanding and monitoring of microcirculatory dysfunction in sepsis patients.

Area of Science:

  • Critical care medicine
  • Physiology
  • Pathophysiology

Background:

  • Microcirculatory dysfunction is central to severe sepsis and septic shock.
  • Current microcirculation monitoring in human sepsis is limited and not standard clinical practice.
  • Challenges include data interpretation, relating sublingual to organ microcirculation, and lack of sequential parameters.

Purpose of the Study:

  • To bridge experimental data on abdominal organ microvascular derangement kinetics with clinical microcirculatory findings.
  • To provide a comprehensive overview of microcirculatory changes in the early phase of severe sepsis/septic shock.
  • To aid in developing therapeutic and prognostic parameters for sepsis.

Main Methods:

  • Review of experimental studies on microvascular derangement kinetics in sepsis.

More Related Videos

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Related Experiment Videos

Last Updated: Jun 12, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

  • Analysis of clinical studies on microcirculatory findings in early severe sepsis/septic shock.
  • Synthesis of experimental and clinical data to identify key microcirculatory changes.

    • Main Results:

    • Detailed kinetics of microvascular changes in experimental sepsis models.
    • Correlation of these kinetics with clinical observations in human sepsis.
    • Identification of gaps in understanding and potential areas for future research.

    Conclusions:

    • Understanding the kinetics of microvascular derangement is crucial for sepsis management.
    • Further research is needed to integrate microcirculatory monitoring into clinical practice.
    • Bridging experimental and clinical findings can lead to better therapeutic strategies and prognostication.