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Controlled intraoral delivery of hydrocortisone sodium succinate
I M Brook1, R van Noort, A V Pandurangi
1School of Clinical Dentistry, University of Sheffield, England.
Oral Surgery, Oral Medicine, and Oral Pathology
|April 1, 1991
Abstract:
Controlled release of hydrocortisone sodium succinate from a device consisting of a drug containing a core of polymethyl methacrylate was achieved by the use of a design incorporating impermeable barriers to drug diffusion and the use of a semipermeable membrane. Initial in vivo study showed sustained intraoral delivery of hydrocortisone sodium succinate during a 6-day period.