Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Siglec-10 expression is up-regulated in activated human CD4<sup>+</sup> T cells.

Human immunology·2020

Same author

The Great Pretender: early syphilis mimicking acute sclerosing cholangitis.

Frontline gastroenterology·2017

Same author

Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release.

International journal of obesity (2005)·2017

Same author

A fatal case of transplantation-mediated alloimmune thrombocytopenia following liver transplantation.

Hematology (Amsterdam, Netherlands)·2016

Same author

GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women.

International journal of obesity (2005)·2015

Same author

Maturity-onset diabetes of the young type 5 in a family with diabetes and mild kidney disease diagnosed by whole exome sequencing.

Internal medicine journal·2014

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Monotonic responses from monochromatic optical particle counters.

J C Barnard, L C Harrison

|June 5, 2010

Summary

Optical particle counters (OPCs) can achieve a monotonic sizing response for specific particle refractive indices. This is possible by optimizing collection optics in nonresonant cavity designs, unlike resonant cavity instruments.

Area of Science:

Optical Physics
Particle Characterization
Metrology

Background:

Optical particle counters (OPCs) are crucial for sizing particles.
Ensuring a monotonic response is key for accurate sizing.
Mie theory provides the framework for understanding light scattering by particles.

Purpose of the Study:

To investigate the conditions for achieving a monotonic response in optical particle counters.
To determine the influence of particle refractive index on OPC response.
To explore the role of collection optics geometry in monotonic sizing.

Main Methods:

Utilizing Mie theory to model light scattering.
Simulating OPC responses under monochromatic illumination.
Systematically varying angular collection limits for coaxial optics.

More Related Videos

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

Main Results:

A nearly monotonic OPC response is achievable for nonresonant cavity designs with specific collection optics.
The effectiveness depends on the particle's refractive index.
Resonant cavity instruments showed no monotonic response, except for particles with high imaginary refractive index components.

Conclusions:

Optimizing collection optics in nonresonant cavity OPCs can yield monotonic sizing for certain refractive indices.
Resonant cavity OPCs are less suitable for monotonic sizing unless particles have specific optical properties.
This research informs the design of more accurate particle sizing instruments.