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Updated: Jun 12, 2026
06:08
Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
The Inhibitory Effect of Phytoclear-EL1 on Melanogenesis
Kee Suck Suh1, Jae Woo Baek, Tae Kwon Kim
1Department of Dermatology, Kosin University College of Medicine, Busan, Korea.
Annals of Dermatology
|June 5, 2010
Summary
Phytoclear-EL1, an extract from Euphorbia lathyris seeds, effectively inhibits melanogenesis. This study shows its potential for controlling hyperpigmentation disorders by reducing melanin production.
Area of Science:
- Dermatology and Cosmetology
- Biochemistry
Background:
- Phytoclear-EL1, derived from Euphorbia lathyris seeds, exhibits skin whitening properties.
- Its efficacy is linked to the inhibition of tyrosinase activity, a key enzyme in melanin synthesis.
Purpose of the Study:
- To evaluate the inhibitory effects of Phytoclear-EL1 on melanogenesis.
- To assess its potential as a treatment for hyperpigmentary disorders.
Main Methods:
- In vitro studies utilized cultured B-16 melanoma cells to assess changes in cell number, melanin content, and tyrosinase activity.
- In vivo studies involved 30 human volunteers with UVB-induced hyperpigmentation, applying Phytoclear-EL1 twice daily for 7 weeks.
- Both subjective and objective measurements were employed to evaluate treatment efficacy.
Main Results:
- In vitro, Phytoclear-EL1 (5 µg/ml) significantly decreased B-16 melanoma cell number, melanin content, and tyrosinase activity compared to controls.
- In vivo, 0.2% Phytoclear-EL1 showed significant improvements in skin L values (chromameter) and received higher subjective scores for hyperpigmentation control compared to placebo.
- Results indicate Phytoclear-EL1 effectively inhibits melanogenesis both in vitro and in vivo.
Conclusions:
- Phytoclear-EL1 demonstrates significant inhibitory effects on melanogenesis.
- It shows promise as a potential topical treatment for managing hyperpigmentary disorders.
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