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Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 12, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Dermatofibrosarcoma protuberans arising from a burn scar.

Jong Keun Seo1, Kyung Jong Cho, Ju Hyun Kang

  • 1Department of Dermatology, Inje University School of Medicine, Busan, Korea.

Annals of Dermatology
|June 5, 2010
PubMed
Summary

Dermatofibrosarcoma protuberans is a rare skin cancer that can develop in burn scars. This report details a third documented case of this rare cancer arising in a burn scar, highlighting its unusual occurrence.

Keywords:
Burn scarDermatofibrosarcoma protuberans

Related Experiment Videos

Last Updated: Jun 12, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
07:45

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment

Published on: November 6, 2018

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Malignant neoplasms in burn scars are documented, with 25 cases of burn scar sarcomas previously reported in literature.
  • Dermatofibrosarcoma protuberans (DFSP) is an exceptionally rare form of skin cancer, with only two prior cases linked to burn scars.

Observation:

  • A 43-year-old Korean male presented with multiple erythematous clustered plaques, nodules, and a subcutaneous mass on his chest.
  • The patient had a history of severe burn injury at the age of 8 years, with the lesions developing in the scarred area.

Findings:

  • Biopsy confirmed the diagnosis of dermatofibrosarcoma protuberans.
  • The tumor was surgically excised with wide margins, encompassing the adjacent burn scar tissue.

Implications:

  • This case represents the third documented instance of dermatofibrosarcoma protuberans originating in a burn scar.
  • Further research into the pathogenesis and risk factors for DFSP in burn scars is warranted.