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Updated: Jun 12, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Successful desensitization in a crossmatch positive living-related kidney transplant recipient using a
Lan Zhu1, Zhengbin Lin, Ying Xiang
1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Abstract:
This is a case of one patient who was treated with a bortezomib-based desensitization regimen to treat sensitization obtained though a previous transplant lost to chronic rejection. This regimen successfully convert a positive crossmatch to negative, prevented both hyperacute and acute rejections out to 3-months post transplant, and was without any noticeable side effects. This account demonstrates that desensitization by bortezomib combined with plasmapheresis and low-dose IVIG is a possible way to transplant a highly sensitized patient.
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