Related Experiment Videos
Pattern of pathogens and their sensitivity isolated from superficial surgical site infections in a tertiary care
Syed Asad Ali1, S M Tahir, Abdul Sattar Memon
1Department of Surgery, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan. sasadalishah@gmail.com
Background:
Infection is an important cause of morbidity and mortality in surgical patients. Rapidly emerging nosocomial pathogens and the problem of multi-drug resistance necessitates periodic review of isolation patterns and sensitivity in surgical practice. Surgical site infections (SSI) are defined as an infections that occurs at the incision site within thirty days after surgery. Objectives of the study were to determine the pattern of pathogens involved and their antibiotic sensitivity isolated from superficial surgical site infections in a teaching hospital.
Methods:
This observational study was conducted for 1 year from January 2008 to December 2008 in all 4 surgical units of Liaquat University Hospital Hyderabad which caters to patients from low socioeconomic status. Pus culture and sensitivity reports were collected prospectively from hospitalised patients who developed postoperative wound infection. The patients who developed fecal/biliary/urinary fistula or operated for malignancies, and with negative cultures were excluded from the study. Analysis was carried out using SPSS 10.
Results:
During the study period 112 pus culture and sensitivity reports were analyzed. E. coli 68 (60.7%) was the most common organism isolated followed by Klebsiella 23 (20.5%). The least frequent organism was staph. Epidermidis 1 (0.9%). All isolates were sensitive to penicillin derivatives and carbapenem. Quinolones, Aminoglycosides and Monobactum were also showing some promise in our study. However, Cephalosporins were ineffective against most of the important isolates in our study.
Conclusion:
E. coli and klebsiella were the most important isolates form SSI in our study, and penicillin derivatives and carbapenem were showing 100% antibiotic sensitivity to all of the isolates.
Insights
Surgical site infections (SSI) are frequently caused by E. coli and Klebsiella. Penicillin derivatives and carbapenems demonstrate 100% effectiveness against these common pathogens in surgical patients.
Area of Science:
- Infectious Diseases
- Surgical Infections
- Microbiology
Background:
- Surgical site infections (SSI) are a significant cause of patient morbidity and mortality.
- Rising antimicrobial resistance necessitates regular monitoring of pathogen prevalence and antibiotic sensitivity in surgical settings.
- Understanding local resistance patterns is crucial for effective patient management.
Purpose of the Study:
- To identify common pathogens causing superficial surgical site infections (SSI).
- To determine the antibiotic sensitivity patterns of isolated microorganisms.
- To inform empirical antibiotic therapy in a teaching hospital setting.
Main Methods:
- An observational study conducted over one year (2008) in four surgical units.
- Prospective collection of pus culture and sensitivity reports from hospitalized patients with postoperative wound infections.
- Exclusion criteria included fistulas, malignancy surgery, and negative cultures; data analyzed using SPSS 10.
Main Results:
- 112 pus culture and sensitivity reports were analyzed.
- Escherichia coli (E. coli) was the most prevalent organism (60.7%), followed by Klebsiella (20.5%).
- All isolates were sensitive to penicillin derivatives and carbapenems, while cephalosporins showed limited efficacy.
Conclusions:
- E. coli and Klebsiella are the primary causative agents of SSI in this study population.
- Penicillin derivatives and carbapenems exhibited 100% sensitivity against all isolated pathogens.
- Findings highlight the importance of local antibiograms for guiding SSI treatment.
Related Concept Videos
01:29Staphylococcal Skin Infections
01:25Clinical Significance of Antibiotic Resistance
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
01:25Rapid Identification of Pathogens
01:20Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...