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Updated: Aug 11, 2026
Busulfan as a Myelosuppressive Agent for Generating Stable High-level Bone Marrow Chimerism in Mice
Published on: April 1, 2015
[Bone marrow transplantation in the treatment of severe aplastic anemia]
F Locatelli1, M Zecca, L Nespoli
1Clinica Pediatrica, Università di Pavia, IRCCS Policlinico S. Matteo, Italia.
Abstract:
Bone marrow transplantation (BMT) in patient affected by severe aplastic anemia (SAA), is successful in 70-80% of cases, when performed with HLA identical brother or syngeneic twin as donors, and in 11-45% of cases when performed from aploidentical-identical related or HLA identical unrelated donor. The different conditioning regimens (Cy alone or in combination with TBI) have shown similar results in the long term outcomes. Cyclosporin-A is very effective in avoiding rejection and controlling GVHD.
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