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Updated: Jun 12, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Surgery for malignant pleural mesothelioma.

David J Sugarbaker¹, Andrea S Wolf

¹Division of Thoracic Surgery, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. dsugarbaker@partners.org

Expert Review of Respiratory Medicine

|June 8, 2010

Summary

Surgery plays a crucial role in diagnosing and resecting malignant pleural mesothelioma. Understanding surgical pathophysiology aids in refining treatments and improving patient outcomes for this rare cancer.

Area of Science:

Thoracic Surgery
Surgical Oncology
Malignant Pleural Mesothelioma

Background:

Malignant pleural mesothelioma is a rare, aggressive cancer requiring a multimodal treatment approach.
Surgery is integral for diagnosis, staging, and macroscopic complete resection of the tumor.

Purpose of the Study:

To elucidate the multifaceted role of surgery in managing malignant pleural mesothelioma.
To highlight the evolution and indications of surgical procedures like extrapleural pneumonectomy and pleurectomy/decortication.
To emphasize the contribution of surgical pathophysiology to understanding mesothelioma biology and guiding future research.

Main Methods:

Review of surgical techniques: extrapleural pneumonectomy (EP) for locally invasive disease and pleurectomy/decortication (PD) for superficial spread.

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Classification of T4 tumors involving critical mediastinal structures, guiding PD recommendation.

Analysis of trimodality therapy including EP, chemotherapy, and radiation for select patients with advanced disease and favorable prognostic factors.

Main Results:

Surgical goals include macroscopic complete resection, with EP and PD as primary evolving operations.
T4 classification mandates PD if critical mediastinal structures are involved.
Trimodality therapy can lead to extended survival in a subset of patients with favorable prognostic factors.

Conclusions:

Surgical pathophysiology provides critical insights into mesothelioma's biology, histopathology, staging, recurrence patterns, and prognostic factors.
Future research will focus on optimizing patient selection, pathologic and molecular staging, and novel adjuvant therapies for malignant pleural mesothelioma.