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Polyalveolar lobe and congenital cystic adenomatoid malformation type II: are they related?
C A Wagenvoort1, P E Zondervan
1Department of Pathology, Erasmus University Rotterdam, The Netherlands.
Insights
Congenital cystic adenomatoid malformation type II (CCAM) can present with a polyalveolar lobe, a previously undescribed complication. This finding in infants suggests a potential causal link between these rare lung anomalies.
Area of Science:
- Pediatric Pathology
- Respiratory Medicine
- Congenital Malformations
Background:
- Congenital cystic adenomatoid malformation type II (CCAM) is a rare pulmonary malformation.
- Polyalveolar lobe, characterized by an increased number of alveoli, is a distinct lung anomaly.
- The coexistence of CCAM and polyalveolar lobe has not been previously reported.
Abstract:
A left lower polyalveolar lobe in a 28-day-old infant and a right lung with congenital cystic adenomatoid malformation type II in a 17-day-old infant are described. The adenomatoid malformation involved all lobes, but the lower lobe appeared to be mostly replaced by a polyalveolar area, a complication hitherto undescribed. The pronounced increase in number of alveoli in both cases was established by two different morphometric methods and was compared with three normal controls of the same age. The simultaneous occurrence of polyalveolar lobe and congenital cystic adenomatoid malformation type II in the same lung suggests a causal relation between both anomalies. In the grossly abnormal lung tissue of an adenomatoid malformation, polyalveolar areas can easily be overlooked.
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