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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hand hygiene01:23

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
PPE Use in Healthcare Settings II: Doffing01:10

PPE Use in Healthcare Settings II: Doffing

The sequence of removing or doffing PPE starts with the gloves, as they are the most contaminated. Next is removal of the face shield or goggles, as they would interfere with removing other PPE. Then remove the gown, followed by the mask or respirator. Perform hand hygiene between steps if hands become contaminated and immediately after removing all PPE. Generally, the outside front and sleeves of the isolation gown, the goggles or the mask, the respirator, and the face shield are contaminated.
PPE Use in Healthcare Settings I: Donning01:22

PPE Use in Healthcare Settings I: Donning

Donning PPE must be completed before contact with the patient. This process protects from infectious agents. The sequence and action included in each donning are critical, and the steps must be systematic to avoid exposure to pathogens. The institutional policy also needs to be followed while donning PPE. The pre-donning preparations are gathering equipment, inspecting the PPE equipment for tears, holes, or damage, removing jewelry, removing any garments below the elbows, and tying the hair...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

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Are We Reading Patch Test Reactions in a Uniform Way? An International Contact Dermatitis Research Group Study.

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Related Experiment Video

Updated: Jun 12, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Occupational contact dermatitis.

Denis Sasseville1

  • 1Division of Dermatology, McGill University Health Centre, Montreal, QC. denis.sasseville@mcgill.ca.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|June 8, 2010
PubMed
Summary
This summary is machine-generated.

Occupational contact dermatitis, a common work-related skin issue, includes irritant and allergic types. Diagnosis involves history, examination, safety data sheets, and patch testing for effective management.

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
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Last Updated: Jun 12, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Area of Science:

  • Dermatology
  • Occupational Medicine
  • Immunology

Background:

  • Occupational contact dermatitis (OCD) represents 90% of work-related skin disorders.
  • OCD is primarily categorized into irritant contact dermatitis (80% of cases) and allergic contact dermatitis.
  • Both forms typically manifest as eczematous lesions on exposed body areas, particularly the hands.

Purpose of the Study:

  • To review the pathogenesis and clinical presentations of occupational contact dermatitis.
  • To provide diagnostic guidelines for OCD.
  • To outline a rational management approach for OCD.

Main Methods:

  • Meticulous patient history taking.
  • Thorough physical examination of skin lesions.
  • Review of Material Safety Data Sheets (MSDS) to identify irritants and allergens.
  • Comprehensive patch testing for allergic sensitization assessment.

Main Results:

  • OCD is a prevalent work-related condition with distinct irritant and allergic subtypes.
  • Diagnosis requires a multi-faceted approach combining clinical assessment and specific tests.
  • Patch testing is crucial for confirming allergic contact dermatitis.

Conclusions:

  • Accurate diagnosis of OCD is essential for appropriate management.
  • A systematic diagnostic process aids in differentiating irritant from allergic causes.
  • Effective management strategies are crucial for addressing these challenging cases.