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Biokinetics and dosimetric studies about 99mTc(V)-DMSA distribution.

M B L Correia¹, S S L P Magnata, I M S Silva

¹Nuclear Energy Department, Universidade Federal de Pernambuco, Recife, PE, Brazil.

Cellular and Molecular Biology (Noisy-Le-Grand, France)

|June 8, 2010

Summary

This study investigates the biodistribution and radiation dose of technetium-99m labeled dimercaptosuccinic acid (99mTc(V)-DMSA) in mice. Results indicate high bone uptake, suggesting potential for bone metastasis imaging with relatively low soft tissue radiation dose.

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Area of Science:

Nuclear Medicine
Radiopharmaceutical Research
Medical Imaging

Background:

Radiodiagnostic agents require evaluation of biological parameters influencing absorbed radiation dose.
Technetium-99m labeled dimercaptosuccinic acid (99mTc(V)-DMSA) is a radiopharmaceutical used for medullary thyroid carcinoma and proposed for bone metastasis evaluation.

Purpose of the Study:

To investigate the biokinetics and dosimetry of 99mTc(V)-DMSA using an animal model.
To establish the biodistribution profile and estimate radiation absorbed dose for 99mTc(V)-DMSA.

Main Methods:

Preparation of 99mTc(V)-DMSA from an alkalized DMSA kit.
Intravenous administration of 99mTc(V)-DMSA to mice (n=5).
Organ uptake measurement at 30 min, 1h, 5h, and 12h post-injection using a gamma counter and MIRDOSE 3.0 for dose estimation.

Main Results:

Most organs showed peak uptake at 30 minutes.
Highest kidney uptake was 4.81 ± 1.38% activity/g.
Highest bone uptake was 5.49 ± 0.47% activity/g at 1 hour, followed by exponential decrease.
Preliminary dosimetry indicated higher radiation dose to bone compared to soft tissues.

Conclusions:

The biokinetic profile of 99mTc(V)-DMSA was successfully established in an animal model.
Quantification of residence time and radiation dose estimates were performed for 99mTc(V)-DMSA.
The agent shows potential for bone-targeted imaging due to preferential bone uptake and lower soft tissue dose.