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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
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Related Experiment Video

Updated: Jun 12, 2026

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
05:42

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head

Published on: January 3, 2020

Pancreatic insulinoma: current issues and trends.

Dennis Vaidakis1, John Karoubalis, Theodora Pappa

  • 1Third Department of Surgery, Athens General Hospital, Athens, Greece.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|June 8, 2010
PubMed
Summary

Surgery is the primary treatment for insulinomas, offering high success rates. Accurate preoperative localization using CT and endoscopic ultrasonography is crucial for surgical planning and successful outcomes in these rare pancreatic neuroendocrine tumors.

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Gastroenterology

Background:

  • Insulinomas are rare but common pancreatic neuroendocrine neoplasms.
  • Malignancy prediction is challenging based on histology.
  • Reviewing classical knowledge and current trends in diagnosis and treatment.

Observation:

  • Surgery is the preferred treatment for insulinomas with high success rates.
  • Medical treatment is an option for non-surgical candidates.
  • Preoperative localization is essential for surgical planning.

Findings:

  • Combined biphasic thin section helical CT and endoscopic ultrasonography (EUS) achieve nearly 100% sensitivity for insulinoma localization.
  • Intraoperative localization often requires laparoscopic ultrasound.
  • EUS-guided fine needle tattooing serves as an alternative localization method.

Implications:

  • Laparoscopic resection is recommended for benign insulinomas.
  • Pancreatectomy is reserved for large or potentially malignant tumors.
  • Accurate localization improves surgical success rates and patient outcomes.