Related Experiment Video
Updated: Jun 12, 2026
Oral Health Assessment by Lay Personnel for Older Adults
Published on: February 2, 2020
A community-based RCT for oral cancer screening with toluidine blue
W W-Y Su1, A M-F Yen, S Y-H Chiu
1Division of Biostatistics, Graduate Institute of Epidemiology/Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Room 533, No. 17, Hsu-chow Road, Taipei, 100, Taiwan.
Abstract:
Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10(-5)) was non-significantly 21% lower than that in the control group (35.4 x 10(-5)).
