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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jun 12, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Bone continuum of cancer.

Allan Lipton1

  • 1Department of Medicine and Oncology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA. alipton@hmc.psu.edu

American Journal of Clinical Oncology
|June 8, 2010
PubMed
Summary

Managing bone loss and skeletal complications in cancer patients is crucial for quality of life. Research is exploring new therapies beyond bisphosphonates for bone metastases from solid tumors and multiple myeloma.

Area of Science:

  • Oncology
  • Bone Biology
  • Cancer Metastasis

Background:

  • Bone metastases are a common complication in patients with solid tumors (e.g., breast, prostate) and multiple myeloma.
  • Skeletal complications significantly impact patient quality of life, causing pain, hypercalcemia, fractures, and spinal instability.
  • Current FDA-approved therapy for metastatic bone disease primarily involves bisphosphonates.

Purpose of the Study:

  • To review the current landscape of managing bone loss and symptomatic bone metastases.
  • To highlight the importance of understanding biomolecular pathways for identifying novel therapeutic targets.
  • To discuss emerging therapeutic options in advanced clinical development.

Main Methods:

  • Review of current literature on bone metastases and skeletal complications.

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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Related Experiment Videos

Last Updated: Jun 12, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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  • Analysis of established and investigational therapeutic strategies.
  • Focus on advancements in understanding cancer-related bone disease.

    • Main Results:

    • Bone metastases lead to significant morbidity, including cancer-related pain, the most common cause.
    • Bisphosphonates are the current standard of care for metastatic bone disease.
    • Novel therapeutic targets and drugs are under investigation, with some in late-stage development.

    Conclusions:

    • Effective management of bone metastases is essential for patient care and quality of life.
    • Advances in understanding cancer's effect on bone are paving the way for new treatments.
    • New therapeutic options are anticipated to become available soon for bone loss and symptomatic bone metastases.