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Updated: Jun 12, 2026

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

Chronic Salmonella infected mouse model.

Shaoping Wu1, Rong Lu, Yong-guo Zhang

  • 1Department of Medicine, University of Rochester, USA.

Journal of Visualized Experiments : Jove
|June 8, 2010
PubMed
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This summary is machine-generated.

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This study details a chronic Salmonella typhimurium mouse model for long-term infection research. The protocol covers bacterial culture, animal gavage, and persistence detection for studying host-bacterial interactions.

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Salmonella typhimurium infection is widely studied in mouse models, primarily focusing on acute inflammation and infection.
  • Research on chronic Salmonella infection in vivo is limited, hindering the study of long-term host-bacterial interactions.

Purpose of the Study:

  • To establish and detail a methodology for a chronic bacterial infected mouse model using Salmonella typhimurium.
  • To enable long-term studies on host-bacterial interactions, signal transduction, and tumorigenesis in the gastrointestinal tract.

Main Methods:

  • Establishment of a chronic Salmonella typhimurium infection model with over 6 months of intestinal colonization.
  • Detailed protocol for preparing bacterial cultures and gavage administration to mice.

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Last Updated: Jun 12, 2026

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

  • Method for detecting Salmonella persistence within the mouse gastrointestinal tract.

    • Main Results:

    • Successful establishment of a chronic Salmonella typhimurium mouse model.
    • A comprehensive protocol for bacterial culture, gavage, and detection of Salmonella persistence is provided.
    • The model allows for the investigation of long-term host-bacterial dynamics.

    Conclusions:

    • The developed protocol facilitates the use of a chronic Salmonella-infected mouse model.
    • This model is valuable for exploring crucial biological and microbiological questions related to persistent infections.
    • Aids researchers in studying chronic inflammation, host-pathogen interactions, and potential tumorigenesis.