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Updated: Feb 10, 2026

Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice
Published on: June 8, 2022
Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
Heike Tost1, Dieter F Braus, Shabnam Hakimi
1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany. tosth@mail.nih.gov
Abstract:
Structural remodeling has been observed in the human brain over periods of weeks to months, but the molecular mechanisms governing this process remain incompletely characterized. Using multimodal pharmaco-neuroimaging, we found that acute D2 receptor blockade induced reversible striatal volume changes and structural-functional decoupling in motor circuits within hours; these alterations predicted acute extrapyramidal motor symptoms with high precision. Our findings suggest a role for D2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans.
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