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The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes
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Complementary positional proteomics for screening substrates of endo- and exoproteases

Petra Van Damme1, An Staes, Silvia Bronsoms

  • 1Department of Medical Protein Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium.

Nature Methods
|June 8, 2010
PubMed

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...