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Related Experiment Video

Updated: Jun 12, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Two lung masses with different responses to pemetrexed.

Kwang Young Park1, Jae Wook Jung, Seung Bum Nam

  • 1Department of Internal Medicine, Korea Cancer Center Hospital, Seoul, Korea.

The Korean Journal of Internal Medicine
|June 8, 2010
PubMed
Summary

Tumors in the same patient, even with identical histology, can exhibit varying responses to chemotherapy. This highlights the importance of personalized treatment strategies for lung cancer.

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Area of Science:

  • Oncology
  • Molecular Pathology
  • Cancer Therapeutics

Background:

  • Lung masses in a single patient can present with similar histological features.
  • Initial response to chemotherapy (gemcitabine and carboplatin) was comparable for both masses.
  • Second-line treatment with pemetrexed revealed differential responses after tumor regrowth.

Observation:

  • Two lung masses in one patient displayed identical histology.
  • Both masses initially responded well to gemcitabine and carboplatin chemotherapy.
  • Post-progression, the masses showed distinct responses to pemetrexed therapy.

Findings:

  • Histologically similar lung tumors can possess divergent molecular profiles.
  • Metastatic progression may lead to distinct pathogenetic pathways and chemosensitivity.
Keywords:
Drug resistanceLung neoplasmsNeoplasms, multiple primaryPemetrexed

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Last Updated: Jun 12, 2026

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  • Differential drug responses underscore tumor heterogeneity within a single patient.

    • Implications:

    • Recognizing intra-patient tumor heterogeneity is crucial for effective cancer treatment.
    • Personalized therapeutic approaches may be necessary even for histologically similar tumors.
    • Further research into the molecular mechanisms driving differential drug response is warranted.