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Published on: July 11, 2016

Stenotrophomonas maltophilia: Significant contemporary hospital pathogen - review

O Nyc1, J Matejková

  • 1Department of Clinical Microbiology, 2nd Faculty of Medicine, Charles University, 150 06, Prague, Czech Republic.

Folia Microbiologica
|June 8, 2010
PubMed

Insights

Stenotrophomonas maltophilia is an opportunistic pathogen causing infections in hospitalized patients. Its increasing antibiotic resistance, especially to trimethoprim-sulfamethoxazole, limits treatment options, necessitating improved infection control and antimicrobial strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Stenotrophomonas maltophilia (Sm) is an opportunistic pathogen frequently identified in hospital settings.
  • Its prevalence is linked to invasive medical procedures and antibiotic use.
  • Sm infections are often associated with biofilms, complicating treatment.

Purpose of the Study:

  • To highlight the clinical significance of Stenotrophomonas maltophilia as an opportunistic pathogen.
  • To underscore the challenges posed by its intrinsic and acquired antibiotic resistance.
  • To emphasize the need for enhanced infection control and rational antimicrobial strategies.

Main Methods:

  • Literature review on Stenotrophomonas maltophilia epidemiology and resistance patterns.
  • Analysis of clinical implications of Sm infections, particularly in immunocompromised patients.
  • Discussion of current and future treatment challenges and preventive measures.

Main Results:

  • Stenotrophomonas maltophilia is a growing concern in healthcare-associated infections.
  • High levels of intrinsic and acquired antibiotic resistance, including to trimethoprim-sulfamethoxazole, are evident.
  • Biofilm formation is a key factor in Sm pathogenicity and treatment resistance.

Conclusions:

  • Effective nosocomial infection control and judicious antibiotic use are crucial.
  • Development of novel antimicrobial agents and treatment strategies is necessary.
  • Optimized selection and testing of antimicrobials are vital for managing Sm infections.

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