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Related Experiment Video

Updated: Jun 12, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

Surgical factors affecting return of renal function after partial nephrectomy.

Janet Colli¹, Benjamin Martin, Matthew Purcell

¹VAMC, University of Alabama, Birmingham, AL, USA. jan.colli@ccc.uab.edu

International Urology and Nephrology

|June 8, 2010

Summary

Longer anesthesia and clamp times impact early kidney function after partial nephrectomy. Intraoperative bleeding, however, affects renal function long-term, highlighting the importance of minimizing blood loss for better recovery.

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Last Updated: Jun 12, 2026

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Urology
Nephrology
Surgical Oncology

Background:

Nephron-sparing surgery is the standard for small renal tumors.
Partial nephrectomy aims to preserve renal function.

Purpose of the Study:

Investigate operative factors influencing renal function recovery post-partial nephrectomy.
Identify predictors of early and late renal function changes.

Main Methods:

Retrospective review of 141 partial nephrectomy patients.
Assessed renal function (creatinine clearance) preoperatively and postoperatively (1 day, 6 months).
Analyzed anesthesia time, clamp time, bleeding, and tumor size using multivariate regression.

Main Results:

Increased anesthesia and clamp times correlated with decreased early renal function.
Tumor size and hematocrit changes predicted late renal function decline.
Postoperative hematocrit changes were the primary predictor of reduced renal function at 6 months.

Conclusions:

Prolonged clamp and anesthesia times affect early, but not late, renal function.
Intraoperative bleeding negatively impacts renal function at both early and late stages.
Minimizing blood loss is crucial for renal function recovery after partial nephrectomy.