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Antihumoral rejection therapy by proteasome inhibitor bortezomib: a case series

Nils Lachmann1, Manuela Schütz, Klemens Budde

  • 1Center for Tumor Medicine, HLA Laboratory, Charité- Universitätsmedizin Berlin, Berlin, Germany.

Clinical Transplants
|June 8, 2010
PubMed

These three case reports strongly support previously published data on the usefulness of bortezomib as an innovative and potent antihumoral rejection therapeutical. Contrary to the current, conventional therapeutic regimens including rituximab, PPH and IVIg the administration of bortezomib led to significantly decreased DSA levels facilitating prolonged allograft survival in two out of three cases. The present data might also suggest that the time point of first administration of bortezomib as therapeutic agent is of high importance for the outcome since progressed graft deterioration due to long persisting DSA cannot be reversed.

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