Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chambers of the Heart

Chambers of the Heart

The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...

Cardiomyopathy IV: Restrictive Cardiomyopathy

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

Mitral Stenosis I: Introduction

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

Mitral Valve Prolapse I: Introduction

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of postmortem histopathological changes in dental pulp of rats after drowning in water.

Forensic science, medicine, and pathology·2025

Same author

Frequency and pattern of skull base and vault fracture in isolated head trauma.

Chinese journal of traumatology = Zhonghua chuang shang za zhi·2025

Same author

Decoding Time of Death: Histopathological Dynamics of Intervertebral Discs as a Novel Marker for Postmortem Interval Estimation.

Diagnostics (Basel, Switzerland)·2025

Same author

Morphometric Examination of the Larynx in Turkish Population.

Journal of voice : official journal of the Voice Foundation·2024

Same author

Relationship between optic nerve length and interoptic angle in the prediction of optic chiasm location.

Neurocirugia (English Edition)·2024

Same author

Intradural anatomy and mobilization techniques of oculomotor, trochlear and abducens nerve after microsurgical dissection: a cadaveric study.

Neurocirugia (English Edition)·2024

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Single ventricle cardiac defect.

Bulent Eren¹, Nursel Turkmen, Nurset Turkmen

¹Uludag University Medical Faculty, Forensic Medicine Department, Council of Forensic Medicine of Turkey Bursa Morgue Department, 16059, Bursa, Turkey.

JPMA. the Journal of the Pakistan Medical Association

|June 10, 2010

Summary

This summary is machine-generated.

A rare single ventricle heart defect caused a ten-month-old infant's death. Autopsy revealed a large heart with one ventricle, highlighting the pathology's severity.

More Related Videos

Murine Fetal Echocardiography

Murine Fetal Echocardiography

Published on: February 15, 2013

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

Murine Fetal Echocardiography

Murine Fetal Echocardiography

Published on: February 15, 2013

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

Pediatric Cardiology
Congenital Heart Defects
Forensic Pathology

Background:

Single ventricle heart is a rare congenital cardiac anomaly characterized by a single ventricular chamber.
This condition presents complex functional and physiological defects, often leading to severe health complications.

Observation:

A ten-month-old infant presented with vomiting and diarrhea, leading to rapid deterioration and death.
Autopsy revealed significant cyanosis of the nails and ears, indicating systemic hypoxia.
Internal examination showed a large heart (60g) with a single ventricle lacking septation.

Findings:

The autopsy confirmed a single ventricle heart, a rare and severe congenital abnormality.
The absence of a ventricular septum was a key pathological finding.
The case highlights the critical nature of single ventricle defects in pediatric mortality.

Implications:

This case underscores the importance of timely diagnosis and management of congenital heart defects.
The medico-legal aspect emphasizes the need for thorough autopsy in unexplained pediatric deaths.
Understanding rare cardiac pathologies like single ventricle is crucial for improving pediatric survival rates.