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Related Experiment Video

Updated: Jun 12, 2026

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes

Published on: June 27, 2025

Abruptio placenta and adverse pregnancy outcome.

Nazli Hossain¹, Nusrat Khan, Syeda Seema Sultana

¹Department of Obstetrics & Gynecology Unit-3, Civil Hospital & Dow University of Health Sciences,1-3 Karachi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association

|June 10, 2010

Summary

Abruptio placenta, a serious pregnancy complication, is linked to higher parity and earlier gestational age as significant risk factors. These pregnancies result in poor maternal and fetal outcomes, including high perinatal mortality.

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Area of Science:

Obstetrics and Gynecology
Perinatal Medicine
Reproductive Health

Background:

Abruptio placenta is a significant obstetric emergency.
Understanding its risk factors is crucial for improving maternal and fetal outcomes.

Purpose of the Study:

To identify and analyze the risk factors associated with abruptio placenta.
To determine the impact of abruptio placenta on maternal and fetal health.

Main Methods:

A case-control study was conducted involving 81 women diagnosed with abruptio placenta after 28 weeks of gestation.
Controls consisted of women with live births during the same study period (January-December 2008).
Data were collected from hospital registers, comparing demographic and clinical characteristics.

Main Results:

Abruptio placenta occurred in 3.75% of deliveries.
Significant risk factors identified include higher parity (54% were second, third, or fourth gravida) and earlier gestational age (mean 34 weeks, 51% preterm delivery).
High perinatal mortality (66%) and maternal deaths (2) were observed, with vaginal bleeding and absent fetal heart sounds being common clinical signs.

Conclusions:

Abruptio placenta is associated with adverse maternal and fetal outcomes.
Parity and gestational age are significant predictors of abruptio placenta.
Early identification and management are critical for mitigating severe complications.