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Microwave-assisted copper(II)-catalyzed one-pot four-component synthesis of multifunctionalized dihydropyridines

Kalyan Kumar Pasunooti1, Chantel Nixon Jensen, Hua Chai

  • 1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical, Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Journal of Combinatorial Chemistry
|June 10, 2010
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.