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Updated: Jun 12, 2026

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
Published on: June 7, 2018
Cocaine and amphetamine related transcript (CART) inhibits context induced reinstatement of reward seeking
Bradley J King1, Teri M Furlong, Gavan P McNally
1School of Psychology, The University of New South Wales, Sydney, NSW, 2052, Australia.
Abstract:
We studied the role of cocaine and amphetamine related transcript (CART) in regulating context induced reinstatement (renewal) of reward seeking. Rats were trained to respond for alcoholic beer in context A before extinction in context B. Rats were tested for responding in context A (ABA) and context B (ABB). Intracerebroventricular (ICV) infusions of the active fragment CART55-102 but not the inactive fragment CART1-27 before test prevented ABA renewal of extinguished responding. ICV CART55-102 had no effect on responding in the extinction context (ABB). ICV CART55-102 also altered the profile of behavioral responses observed on test in the training (ABA) but not extinction (ABB) context. These results identify a novel role for CART in preventing reinstatement of reward seeking.
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