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[Prognosis in ankylosing spondylitis].

U Diethelm1, G Schüler

  • 1Medizinisches Zentrum, Abt. Rheumatologie, Bad Ragaz.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis
|May 21, 1991
PubMed
Summary
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Ankylosing spondylitis is a chronic condition causing pain and stiffness, but most patients experience mild disability after 40 years. While quality of life is slightly reduced, many maintain employment with necessary job adaptations.

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Context:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
  • Understanding the long-term prognosis and natural history of AS is crucial for patient management and healthcare planning.

Purpose:

  • To synthesize current literature on the prognosis and natural history of ankylosing spondylitis.
  • To provide insights into disease progression, disability, mortality, and quality of life in AS patients.

Summary:

  • Ankylosing spondylitis is characterized by pain and stiffness, particularly in the first decade of the disease.
  • While mortality data is debated, a small subset of patients may experience reduced survival.
  • After 40 years, approximately 90% of patients report none or mild disability, with a generally slight reduction in quality of life.

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  • Most individuals remain employed, though job adaptations and vocational counseling are often beneficial.

    • Impact:

    • Provides a comprehensive overview of ankylosing spondylitis outcomes for clinicians and researchers.
    • Highlights the generally favorable long-term functional prognosis for the majority of AS patients.
    • Emphasizes the importance of supportive measures like vocational counseling to maintain employment and quality of life.