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Formulation and evaluation of novel micellar nanocarrier for nasal delivery of sumatriptan
Ratnesh Jain1, Swapna Nabar, Prajakta Dandekar
1Department of Pharmaceutical Sciences & Technology Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai 400 019, India.
Aim:
The investigation was aimed at designing a micellar nanocarrier of sumatriptan for nose-to-brain delivery and to identify the probable pathway of drug transport to the brain.
Materials & Methods:
Micellar nanocarriers were formulated using various safe and acceptable excipients. Optimized formulation was characterized for particle size by multiangle dynamic light scattering, small-angle neutron scattering and cryo-transmission electron microscopy. (99m)Tc was used as a radiolabeling agent to radiolabel sumatriptan for in vivo studies.
Results:
Various characterization studies demonstrated the nanometric, homogenous and spherical nature of the developed micellar nanocarrier. Biodistribution and autoradiography studies in rats showed a significantly higher brain uptake of sumatriptan micellar nanocarrier as compared with sumatriptan solution.
Conclusion:
Preliminary investigations in rats indicated the potential of the developed micellar nanocarrier for nose-to-brain delivery of sumatriptan. These investigations in lower animals provided an excellent lead to further evaluate the formulation in higher animals and finally in clinical settings.
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