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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

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Palivizumab-resistant human respiratory syncytial virus infection in infancy

Ortwin Adams1, Linda Bonzel, Alexander Kovacevic

  • 1Institute of Virology, University Children's Hospital, Heinrich-Heine University, Düsseldorf, Germany. ortwin.adams@uni-duesseldorf.de

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 10, 2010
PubMed

Insights

Palivizumab-resistant respiratory syncytial virus (RSV) emerged in an infant receiving treatment. Mutations in the virus caused resistance to palivizumab, impacting its effectiveness.

Area of Science:

  • Virology
  • Immunology
  • Antiviral Drug Development

Background:

  • Respiratory Syncytial Virus (RSV) is a major cause of respiratory illness in infants.
  • Palivizumab is a monoclonal antibody used for RSV prophylaxis.
  • Viral resistance to therapeutic agents is a significant clinical concern.

Observation:

  • RSV was isolated from an infant undergoing palivizumab therapy.
  • The isolated virus exhibited reduced susceptibility to palivizumab.
  • Viral evolution under selective pressure was observed.

Findings:

  • A specific mutation at codon 276 conferred significant palivizumab resistance.
  • A secondary mutation at codon 272 was identified.
  • Extensive viral passage resulted in complete loss of palivizumab binding.

Implications:

  • Emergence of palivizumab-resistant RSV poses a challenge to current prevention strategies.
  • Understanding viral mutation pathways is crucial for developing next-generation antivirals.
  • Monitoring viral resistance is essential for effective RSV treatment and control.

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