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Strategies to improve adherence with medications in chronic, 'silent' diseases representing high cardiovascular risk

Anju Parthan1, Gábor Vincze, Donald E Morisky

  • 1Mapi Values, 15 Court Square, Suite 620, Boston, 02108, USA. anju.parthan@mapivalues.com.

Expert Review of Pharmacoeconomics & Outcomes Research
|June 10, 2010
PubMed

Insights

Improving medication adherence for chronic diseases like diabetes, hypertension, and dyslipidemia is crucial. A patient-centric approach, addressing individual barriers, is key to enhancing treatment persistence and avoiding complications.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetes, hypertension, and dyslipidemia pose significant health burdens, necessitating effective management.
  • Achieving glycemic control, optimal blood pressure, and low-density lipoprotein cholesterol (LDL-C) is vital for preventing long-term complications.
  • Patient adherence and persistence to treatment regimens are critical for managing these chronic, often asymptomatic, diseases.

Purpose of the Study:

  • To review the factors influencing medication adherence in chronic diseases.
  • To highlight the importance of a patient-centric approach in developing adherence interventions.
  • To suggest methodologies for future research in medication adherence.

Main Methods:

  • Literature review on medication-taking behavior in chronic, nonsymptomatic diseases.
  • Categorization of adherence-related factors into health system, social/economic, condition-related, therapy-related, and patient-related domains.
  • Discussion of existing interventions and the need for patient-specific strategies.

Main Results:

  • Medication-taking behavior in chronic diseases is generally low, with reported adherence varying widely.
  • Nonadherence is a multidimensional issue influenced by various interconnected factors.
  • Current interventions to improve adherence lack clear superiority, emphasizing the need for tailored approaches.

Conclusions:

  • Identifying individual barriers and implementing patient-specific self-management plans are essential for improving adherence.
  • A 'patient-centric' approach, recognizing that 'one size does not fit all,' is crucial for intervention design.
  • Well-designed observational studies with long follow-up periods and multiple adherence measurements are needed to advance the field.

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