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Impact of innate and environmental factors on wheezing persistence during childhood

Jocelyne Just1, Samira Belfar, Stéphanie Wanin

  • 1Centre de l'Asthme et des Allergies, Groupe Hospitalier Trousseau-La Roche Guyon, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie-Paris 6, Paris, France. jocelyne.just@trs.aphp.fr

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|June 10, 2010
PubMed

Insights

Persistent childhood wheezing is linked to early-life factors. Breastfeeding, pets, and siblings may protect against persistent asthma, while eosinophilia and allergies increase risk.

Area of Science:

  • Pediatric respiratory health
  • Allergy and immunology
  • Environmental health

Background:

  • Persistent asthma often originates in childhood, linked to early respiratory function changes.
  • Understanding early-life factors is crucial for managing childhood asthma.
  • Recurrent wheezing in infancy is a key indicator for asthma development.

Purpose of the Study:

  • To identify innate and environmental risk factors for childhood asthma.
  • To prospectively evaluate wheezing persistence in infants.
  • To determine protective factors against persistent asthma.

Main Methods:

  • Prospective cohort study of infants (<30 months) with recurrent wheezing.
  • Assessment of atopy, environmental exposures, and symptom severity.
  • Re-evaluation at age 6 for wheezing remission or persistence.

Main Results:

  • Wheezing persisted until age 6 in 27% of infants with recurrent wheeze.
  • Risk factors for persistent wheezing included high eosinophil counts, allergic sensitization, and paternal asthma.
  • Protective factors were breastfeeding >3 months, pets at home, and ≥3 siblings.

Conclusions:

  • Atopic factors significantly influence wheezing persistence in childhood.
  • Specific environmental factors demonstrate a protective role against persistent wheezing.
  • This research highlights key targets for asthma prevention strategies.
Abstract

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