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Related Experiment Videos

Dapsone intoxication: clinical course and characteristics.

Kyung Hye Park1, Hyun Kim, Christopher Chongseo Lee

  • 1Department of Emergency Medicine, Jeju National University Hospital, Jeju, Republic of Korea.

Clinical Toxicology (Philadelphia, Pa.)
|June 10, 2010
PubMed
Summary
This summary is machine-generated.

Dapsone overdose can cause methemoglobinemia. Older patients with dapsone intoxication presenting with altered mental status or delayed care faced higher mortality risks.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Dapsone is an antibiotic for leprosy and dermatological conditions.
  • Dapsone use is associated with a risk of methemoglobinemia.
  • Identifying risk factors for mortality in dapsone overdose is crucial.

Purpose of the Study:

  • Analyze clinical characteristics of dapsone ingestion patients in the ED.
  • Identify risk factors for mortality in dapsone intoxication.
  • Compare outcomes between younger and older dapsone-intoxicated patients.

Main Methods:

  • Retrospective observational study of adult ED patients with dapsone-induced methemoglobinemia.
  • Data collected: demographics, clinical, laboratory characteristics, and survival.
  • Comparison of patients ≤55 years vs. >55 years; primary outcome: in-hospital mortality.

Main Results:

  • 46 patients included; intoxication doses ranged from 200 mg to 10,000 mg.
  • Altered mental status more frequent in older patients (>55 years).
  • Shock and mortality were more common in older patients; methemoglobin levels higher in younger patients.

Conclusions:

  • Late presentation and altered mental status predict death in dapsone intoxication.
  • Higher methemoglobin levels were observed in patients who died.
  • Age is a significant factor influencing outcomes in dapsone overdose.