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Effects of amlodipine plus atorvastatin association in hypertensive hypercholesterolemic patients

Giuseppe Derosa1, Pamela Maffioli

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. giuseppe.derosa@unipv.it

Expert Review of Cardiovascular Therapy
|June 10, 2010
PubMed

Insights

The combination of amlodipine and atorvastatin effectively lowers blood pressure and improves lipid profiles in hypertensive, hypercholesterolemic patients. This dual-action therapy offers superior benefits over single-drug treatments for cardiovascular health.

Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Background:

  • Hypertension and hypercholesterolemia are key risk factors for atherosclerosis.
  • Lowering blood pressure and lipid levels is crucial for managing cardiovascular disease.
  • A fixed-dose combination of amlodipine besylate and atorvastatin calcium is now available.

Purpose of the Study:

  • To evaluate the efficacy of amlodipine plus atorvastatin in hypertensive and hypercholesterolemic patients.
  • To compare the combination therapy against monotherapy for blood pressure and lipid profile.
  • To assess the impact on arterial compliance, left ventricular mass, and inflammation.

Main Methods:

  • Comprehensive literature search on amlodipine and atorvastatin.
  • Analysis of data on blood pressure and lipid profiles.
  • Review of available data on arterial compliance, left ventricular mass index, and inflammatory markers.

Main Results:

  • The combination of amlodipine plus atorvastatin significantly reduced blood pressure and improved lipid profiles more effectively than monotherapy.
  • Combination therapy demonstrated enhanced improvements in small-artery compliance.
  • The dual therapy also led to faster and more effective reductions in left ventricular hypertrophy and uric acid levels.

Conclusions:

  • Amlodipine plus atorvastatin combination therapy is more effective than individual drugs in hypertensive and hypercholesterolemic patients.
  • The combination therapy shows benefits in improving arterial compliance and reducing inflammatory markers.
  • This combination therapy may represent a preferred treatment option for patients with co-existing hypertension and hypercholesterolemia.

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