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Updated: Jun 12, 2026
09:54
Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
Published on: April 18, 2019
Stem cells for skin tissue engineering and wound healing.
Ming Chen1, Melissa Przyborowski, Francois Berthiaume
1The Center for Engineering Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Critical Reviews in Biomedical Engineering
|June 10, 2010
Summary
Epidermal stem cells enable skin regeneration, leading to tissue-engineered skin grafts for wound healing. Future research focuses on using various stem cells to regenerate complex skin structures and appendages.
Area of Science:
- Dermatology
- Regenerative Medicine
- Tissue Engineering
Background:
- Epidermal stem cells are crucial for skin regeneration and barrier function.
- Tissue-engineered skin grafts are established products for treating chronic and acute wounds.
- Current skin regeneration methods struggle to restore dermal structures and skin appendages.
Purpose of the Study:
- To review the wound-healing process and current treatment methods.
- To explore the application of various stem cells in skin tissue engineering.
- To discuss future directions for advanced skin regeneration.
Main Methods:
- Overview of conventional and tissue-engineering based wound treatments.
- Review of research on epidermal, embryonic, and adult stem cells for skin regeneration.
- Analysis of stem cell-based approaches for wound healing and appendage regeneration.
Main Results:
- Epidermal stem cells facilitate keratinocyte production for skin barrier formation.
- Tissue-engineered skin grafts have shown success in treating various wounds.
- Limitations exist in regenerating dermis and skin appendages with current technologies.
Conclusions:
- Stem cell therapies, including embryonic and adult stem cells, show promise for overcoming limitations in skin regeneration.
- Further research is needed to fully regenerate complex skin structures and appendages.
- Advanced stem cell strategies are key to improving long-term skin function and appearance.
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01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:22iPS Cell Differentiation
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01:17Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
01:13Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...