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Carbimazole-induced agranulocytosis: does antineutrophil cytoplasmic antibody have a role?
1Department of Medicine, Austin Health, Melbourne, Victoria, Australia. garyyip2001@yahoo.com.au
Abstract:
Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 weeks after commencement of carbimazole for Graves' disease. It may give credence to the theory that implicates antineutrophil cytoplasmic antibodies in the pathogenesis of agranulocytosis induced by antithyroid drugs.
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