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Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina
T Stewart1, N Pavlakis, M Ward
1Department of Cardiology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
Abstract:
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness of the range of toxicity is necessary if repeat toxicity is to be avoided.
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