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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Inflammation01:38

Inflammation

Overview

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Related Experiment Video

Updated: Jun 12, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

Cachexia - an intrinsic factor in wound healing.

Michael F Y Ng1

  • 1Department of Plastic Surgery, Level 5, Ninewells Hospital, Dundee, DD1 9SY, UK. fee_yen@doctors.net.uk

International Wound Journal
|June 10, 2010
PubMed
Summary
This summary is machine-generated.

Cachexia, a complex systemic disease state, significantly impacts wound healing beyond simple malnutrition. This study explores cachexia

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Last Updated: Jun 12, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
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Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Area of Science:

  • Wound healing
  • Systemic diseases
  • Inflammation

Background:

  • Systemic diseases intrinsically affect wound healing.
  • Cachexia, characterized by inflammation and muscle wasting, is linked to malnutrition and potentially impaired healing.
  • Current understanding lacks specific investigation into cachexia's role in human wound healing.

Purpose of the Study:

  • To establish cachexia as an intrinsic factor influencing human wound healing.
  • To compare key mediators of wound healing and cachexia.
  • To investigate inflammation, nitric oxide synthase pathway, collagen deposition, and reepithelialization in cachexia.

Main Methods:

  • Comparative analysis of wound healing mediators and cachexia pathways.
  • Examination of inflammation, nitric oxide synthase (NOS) pathway, collagen deposition, and reepithelialization.

Main Results:

  • The study hypothesizes that cachexia influences wound healing through mechanisms beyond reduced food intake.
  • Comparison reveals shared mediators between cachexia and impaired wound healing processes.
  • Specific mediators like inflammation and collagen deposition are implicated.

Conclusions:

  • Cachexia is presented as a significant intrinsic factor in wound healing.
  • The relationship between cachexia and wound healing is complex, involving systemic inflammation and cellular processes.
  • Further research is warranted to elucidate the precise mechanisms.